Clinical Trials Search Results

Clinical trials provide an important step in discovering new treatments. You can browse the list of current clinical trials below to learn more.

Trials

A Study to Evaluate the Efficacy and Safety of HLX10 in Combination With Chemotherapy and Concurrent Radiotherapy in Patients With Limited-Stage Small Cell Lung Cancer

A Randomized, Double-Blind, International Multicenter, Phase III Study to Evaluate the Anti-Tumor Efficacy and Safety of HLX10 or Placebo in Combination With Chemotherapy and Concurrent Radiotherapy in Patients With Limited-Stage Small Cell Lung Cancer

Sponsor: Shanghai Henlius Biotech
NCT05353257

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D3250R00107 – BURAN: Effects of Benralizumab in Airway Dynamics in Severe Eosinophilic Asthma using Functional Respiratory Imaging Parameters

The aim of this study is to learn more about the drug called benralizumab (Fasenra®) and to better understand how it works in the treatment of severe eosinophilic asthma.

Sponsor: AstraZeneca
NCT05552508

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Identification of Immunological Host Defense Mechanisms Against Nontuberculous Mycobacteria: A pilot Study to Measure Immune Response in Patients with and without Nontuberculous Mycobacterial (NTM) Infection

The purpose of this study is to gain insight into the factors that contribute to protection against NTM. It is hoped that information collected from this study will lead to new treatment options to improve outcomes of patients infected with NTM.

Sponsor: Grant
IRB #: 1085

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Multicenter randomized pragmatic clinical trial comparing two-versus three-antibiotic therapy for pulmonary Mycobacterium avium complex disease

The purpose of this study is to compare the effectiveness and tolerability of a 2-study drug treatment regimen and a 3-study drug treatment regimen in subjects who have recently been diagnosed with pulmonary (lung) disease caused by Mycobacterium avium complex (MAC).

Sponsor: PCORI
IRB#: 1084

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Bronchiectasis Registry

The purpose of the program is to identify a group of people who are interested in receiving information about research studies focused on bronchiectasis and/or non-tuberculosis mycobacteria (NTM) and possibly participating in these research studies.

Sponsor: COPD Foundation
IRB#: 872

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CF Registry

The goal of the Patient Registry is to collect data on individuals with cystic fibrosis (CF) to better understand the illness and ultimately improve the care and survival of those with CF.

Sponsor: CFF
IRB#: 678

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Metastatic Pancreatic Ductal Adenocarcinoma Study

A Randomized, Double-Blind, Placebo-Controlled Study of Nab-Paclitaxel and Gemcitabine With or Without SBP-101 in Subjects Previously Untreated for Metastatic Pancreatic Ductal Adenocarcinoma

Sponsor: Panbela Therapeutics
NCT05254171

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Unresectable Locally Advanced or Metastatic Solid Tumors Study

Open-Label Phase 2 Study of Ladiratuzumab Vedotin (LV) for Unresectable Locally Advanced or Metastatic Solid Tumors (Cohorts for Prostate Cancer and Melanoma open)

Sponsor: Seagen Inc
NCT04032704

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Relapsed/Refractory Follicular Lymphoma Study

Symphony-1: A Phase 1b/3 double-blind, randomized, active-controlled, 3-stage, biomarker adaptive study of tazemetostat or placebo in combination with lenalidomide plus rituximab in subjects with relapsed/refractory follicular lymphoma

Sponsor: Epizyme, Inc
NCT04224493

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Relapsed/Refractory Diffuse Large B-Cell Lymphoma Study

A Phase 2/3, Multicenter Randomized Study of Rituximab-Gemcitabine Dexamethasone-Platinum (R-GDP) With or Without Selinexor in Patients With Relapsed/Refractory Diffuse Large B-Cell Lymphoma (RR DLBCL)

Sponsor: Karyopharm Therapeutics Inc
NCT04442022

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Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma Study

The BURAN Study of Buparlisib (AN2025) In Combination With Paclitaxel Compared to Paclitaxel Alone, in Patients With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma

Sponsor: Adlai Nortye Biopharma Co
NCT04338399

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Locally Advanced/Metastatic Breast or Non-Small Cell Lung Cancer Study

A Phase 1b, Multicenter, Two-Part, Open-Label Study of Trastuzumab Deruxtecan, an Anti-Human Epidermal Growth Factor Receptor-2 (HER2)-ADC, in Combination with Pembrolizumab, an Anti-PD-1 Antibody, in Subjects with Locally Advanced/Metastatic Breast or Non-Small Cell Lung Cancer (NSCLC)

Sponsor: Daiichi Sankyo, Inc
NCT04042701

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Stage IV or Recurrent Non-small Cell Lung Cancer Study

A Phase 2 Randomized Study of Relatlimab Plus Nivolumab in Combination With Chemotherapy vs. Nivolumab in Combination With Chemotherapy as First Line Treatment for Participants With Stage IV or Recurrent Non-small Cell Lung Cancer (NSCLC)

Sponsor: Bristol-Myers Squibb
NCT04623775

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Locally Advanced, Unresectable, PD-L1-Selected Non-Small Cell Lung Cancer Study

A Phase 3, Randomized, Open-Label Study to Compare Ociperlimab (BGB-A1217) Plus Tislelizumab (BGB-A317) Versus Durvalumab in Patients With Locally Advanced, Unresectable, PD-L1-Selected Non-Small Cell Lung Cancer Whose Disease Has Not Progressed After Concurrent Chemoradiotherapy

Sponsor: BeiGene
NCT04866017

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Study to Evaluate the Safety, Efficacy, and Pharmacology of ARINA-1

RVN-301 – A Phase 2a, randomized, double-blind, placebo-controlled study to evaluate the safety, efficacy, and pharmacology of ARINA-1 administered twice daily by nebulizer in adult participants with non-cystic fibrosis bronchiectasis (NCFBE) with excess mucus and cough.

Sponsor: Renovion, Inc.
NCT05495243

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Study to Assess to Efficacy, Safety, and Pharmacokinetics of Orally Administered Epetraborole

MACrO2 – A Phase 2/3, Randomized, Double-Blind, Placebo-Controlled, Multicenter, Prospective Study to Assess to Efficacy, Safety, and Pharmacokinetics of Orally Administered Epetraborole in Patients with treatment-Refractory Mycobacterium avium Complex Lung Disease – Protocol EBO-301

Sponsor: AN2 Therapeutics
IRB#: 2022-029

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Study Evaluating Efficacy, Safety, and Tolerability of BI 1291583 qd

1397-0012 – A randomized, double-blind, placebo-controlled, parallel-group, dose-finding study evaluating efficacy, safety, and tolerability of BI 1291583 qd over at least 24 weeks in patients with bronchiectasis

Sponsor: BI
NCT05238675

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Development of a nontuculous mycobaterial pulmonary disease symptom scale

Development of a nontuberculous mycobaterial pulmonary disease symptom scale

Sponsor: FDA
IRB#: 2022-011

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Study to Assess the Safety, Tolerability and Pharmacokinetics of Brensocatib

INS1007-211 – A single-blind, placebo-controlled, parallel-group study to assess the safety, tolerability and pharmacokinetics of brensocatib administered once daily for 4 weeks in subjects with cystic fibrosis

Sponsor: Insmed
NCT04594369

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Study to Evaluate the Efficacy, Safety Tolerability and Pharmacokinetics of Oral Omadacycline in Treatment-Naïve Adults Subjects with Nontuberculous Mycobaacterial (NTM) Pulmonary Disease

PTK0796-NTM-20203 – A Phase 2b, Double-Blind, Randomized, Parallel-Group, Placebo-Controlled, Multi-Center Study to Evaluate the Efficacy, Safety Tolerability and Pharmacokinetics of Oral Omadacycline in Treatment-Naïve Adults Subjects with Nontuberculous Mycobaacterial (NTM) Pulmonary Disease Caused by Mycobacterium abscessus complex (MABc)

Sponsor: Paratek
NCT04922554

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